The transfer of genetically engineered lymphocytes in melanoma patients: a Phase I dose escalation study
نویسندگان
چکیده
Background Genetically engineered T cells have broadened the opportunity for use of T cell immunotherapy in cancer patients. The possibility of improving T cell efficacy via introduction of additional genes potentially gives them an advantage over TIL. Studies in adoptive T cell transfer suggest that persistence is fundamental to the efficacy of this therapy. This Phase I clinical trial uses TCR TIL 1383I transduced T cells to target the tyrosinase antigen on melanoma cells. Two of the objectives in this clinical trial in stage IV melanoma patients include measuring persistence and monitoring the behavior of tumorreactive T cells in vivo.
منابع مشابه
Cancer regression in patients after transfer of genetically engineered lymphocytes.
Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to mediate objective cancer regression in human patients with metastatic melanoma. However, the generation of tumor-specific T cells in this mode of immunotherapy is often limiting. Here we report the ability to specifically confer tumor recognition by autologous lymphocytes from peripheral blood by using a ...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015